The cause and mechanism of dercums disease remains unknown. Wir stellen einen patienten mit adiposis dolorosa vor, bei dem wir erfolgreich eine intravenose behandlung mit lidocain durchfuhrten. Manifestations were remarkably variable, ranging from complete. The first page of the pdf of this article appears above. The most wellknown symptom of adiposis dolorosa is having more than one painful lipoma. Review of dercums disease and proposal of diagnostic criteria. This disorder has been described to occur commonly in obese. More importantly than which name we use, however, is that we increase recognition of this syndrome by physicians and patients. I think the names adiposis dolorosa and dercums disease will both stay in use. Dercums disease, also known as adiposis dolorosa or lipomatosis dolorosa, is a rare disorder characterized by a generalized and painful growth of the subcutaneous adipose tissue. The understanding of the cause and mechanism of dercum disease remains unknown. A rare cause of breast pain is dercums disease, or adiposis dolorosa, a condition characterized by multiple, often painful.
Adiposis dolorosa is a very uncommon disease, and researchers are not yet certain what causes it. Neuropeptide levels in dercums disease adiposis dolorosa. Dercum disease dd is a rare inflammatory disease of painful subcutaneous fat masses with known. The disease is listed in orphanet 1 and the national organization for rare disorders. Genetic and rare diseases information center gard po box 8126, gaithersburg, md 208988126 tollfree. Intravenose lidocaintherapie bei adiposis dolorosa dercum. The most common locations for painful fat and for lipomas are the extremities, the trunk, the pelvic area, and the buttocks figure 1. Her systemic symptoms included generalized weakness, fatigue, memory impairment, and arthralgias. Dercums disease adiposis dolorosa is a rare disease of unknown etiology characterized by painful subcutaneous adipose tissue deposits with various localization over the body.
Dercums disease is a rare disorder characterized by multiple, painful growths of fatty. Adiposis dolorosa symptoms, diagnosis, treatments and. The main symptoms of dercums disease, according to the early reports, are obesity and painful adipose tissue. We describe two typically affected siblings who were found to have at least 5 affected firstdegree relatives in two generations. Focused ultrasound is an earlystage, noninvasive, therapeutic technology with the potential to improve the quality of life and decrease the cost of care for patients with dercums disease which is also known as adiposis dolorosa which translates to painful fat. Pdf adiposis dolorosa of scalp presenting with severe headache.
Adiposis dolorosa dercums disease is a rare, sporadic disease characterised by generalised obesity with pronounced pain in the adipose. A lipoma is a nonmalignant or benign non cancerous tumor formed from adipose tissue body fat. Adiposis dolorosa wikimili, the best wikipedia reader. Adiposis dolorosa is a condition characterized by painful folds of fatty adipose tissue or the growth of multiple benign noncancerous fatty tumors called lipomas. Adiposis dolorosa, adipositas dolorosa, morbus dercum. These types of articles are always helpful to physicians or medical personnel unfamiliar with dd. Approximately 250 cases have been described in the worlds literature since the original report of the condition by dercum in 1888. First described in 1892 by the american neurologist francis xavier dercum at jefferson medical college in philadelphia, pennsylvania, dercum disease adiposis dolorosa is an unusual progressive syndrome of unknown etiology characterized by multiple painful lipomas that arise in adult life, most often affecting obese postmenopausal women. Adiposis dolorosa ad, or dercum disease, is a rare disorder that was first described in 1888 and characterized by the national organization of rare disorders. This condition occurs most often in women who are overweight or obese, and signs and symptoms typically appear between ages 35 and 50. This condition occurs most often in women who are overweight or obese, and signs. Adiposis dolorosa of scalp presenting with severe headache.
Among the symptoms reported by patients undergoing breast imaging, pain is one of the most common. Although some of the lesions were tender, most were only appreciated with palpation. For language access assistance, contact the ncats public information officer. For immediate, free, and confidential assistance, download or. A rare cause of breast pain is dercums disease, or adiposis dolorosa, a condition characterized by multiple, often. Dercums disease nord national organization for rare disorders. Adiposis dolorosa or dercums disease is a rare lipomatous disorder characterized by painful lipomas. Dercum disease also known as adiposis dolorosa, anders syndrome and dercumvitaut syndrome is a rare condition that is characterized by multiple, painful fatty lipomas benign, fatty tumors that occur chiefly in postmenopausal, obese women of middle age.
The tumors are normally painful and found in multiples on the extremities. The disease is characterized by inflammation of the fatty tissue, being known previously as fatty tissue rheumatism. Familial occurrence of adiposis dolorosa sciencedirect. Adiposis dolorosa is a disease characterized by painful subcutaneous fatty tumors. A cure has not been discovered, but there are treatments that focus on helping the patient deal with pain associated with this disease. A rare cause of breast pain is dercums disease, or adiposis dolorosa, a condition characterized by multiple, often painful subcutaneous. Francis xavier dercum at the university of pennsylvania over a century ago. Adiposis dolorosa, also known as dercums disease, is a rare condition characterized by generalized obesity and fatty tumors in the adipose tissue. The pain is most commonly described by the patients as burning or aching.
Adiposis dolorosa ad is a rare disorder of painful nodular subcutaneous fat accompanied by fatigue, difficulty with weight loss, inflammation, increased fluid in adipose tissue lipedema and. The pain may disappear without treatment but any manual therapy such as. The history of the earlier phases of the development of medicine depends fully as much on objects in bronze, marble and clay as on the written word. Adiposis dolorosa pain management federal practitioner. Adiposis dolorosa is a rare condition characterized by multiple painful lipomas. Her clinical history and histopathologic data suggested adiposis dolorosa dercums disease. Adiposis dolorosa, dercums disease, should be suggested in the presence of multiple many small, oblong, fatty lesions in the subcutaneous fatty tissue in adult patients if they are hyperechoic on ultrasound imaging or blushlike at unenhanced mri.
Adiposis dolorosa should be diagnosed through physical. Adiposis dolorosa, also known as dercums disease or anders disease, is a rare condition characterized by generalized obesity and fatty tumors in the adipose tissue. It consists of a bunch of fat cells enclosed within. Adiposis dolorosa genetic and rare diseases information center.
Dercums disease adiposis dolorosa is a rare disease of unknown etiology. Adiposis dolorosa is more than painful fat request pdf. Dercums is a rare disease that causes painful, fatty growths to appear under the skin, sometimes all over the body. Alternative treatments for dercums disease aka adiposis.
Adiposis dolorosa ad, or dercum disease, is a rare disorder that was first described in 1888. Adiposis dolorosa is listed as a rare disease by the office of rare diseases ord of the national institutes of health nih. If you have problems viewing pdf files, download the latest version of adobe reader. There are a number of associated symptoms, including multiple lipomas, generalized weakness, fatigue, sleep disturbances, constipation, and. Cureus exophytic adiposis dolorosa dercums disease of. Adiposis dolorosa genetic and rare diseases information. Alerts and notices synopsis adiposis dolorosa, also known as dercum disease, is an uncommon condition characterized by the development of numerous painful subcutaneous lipomas. Adiposis dolorosa is rare and to our knowledge, the prevalence in the united states or worldwide has not been established. In this article, we report a case of rather large exophytic adiposis dolorosa causing difficulties with ambulation, and our surgical management of the disorder. Dercums disease white paper information for healthcare providers by karen louise herbst, ph. Here, we report on 2 patients with dercums disease, who were successfully treated with pregabalin and manual lymphatic drainage, and another. When palpable lipomas exist they vary in size and firmness.
Tagged adiposis dolorosa, angiolipomas, chronic pain, dercums disease, dercums disease. Pdf a 46yearold female, known case of adiposis dolorosa since. The condition predominates in postmenopausal, often obese, women. Dercums disease is a syndrome of painful growths in subcutaneous fat. To our knowledge, this is the first reported case of a large exophytic adiposis dolorosa of the upper medial thigh causing problems. Review of dercums disease and proposal of diagnostic criteria, diagnostic methods, classification and management. Synonyms of the disease that can be found in the medical literature include dercums disease, morbus dercum, adiposis dolorosa, adiposalgia. In the united states, a rare disease is generally considered to be a disease that affects fewer than 200,000 people. Adiposis dolorosa is a rare condition characterized by the growth of multiple, painful, lipomas benign, fatty tumors. Adiposis definition of adiposis by the free dictionary. We read with interest the editorial on the clinical use of intranasal esketamine in treatmentresistant depression by editorinchief cynthia geppert in the october 2019 issue of federal practitioner. Case report infections preceding the development of dercum disease. Dercums disease adiposis dolorosa, or lipomatous dolorosa morbus dercum was first described by the american neurologist francis dercum in 1888. Dercum disease adiposis dolorosa is a syndrome of painful fatty growths with altered lymphatics 1,2.